@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus @regionerne @novonordiskfond Lastly, thanks to all investigators and supporting personel #StrongWork
#MoreToCome
@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus Many thanks for the support:
♥️ Danish Regions Medicinpulje @regionerne and ♥️ The Novo Nordic Fundation @novonordiskfond
♥️ The supporting sites
♥️ And patients ♥️ and relatives ♥️ in particular
@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus In conclusion, low-dose prostacyclin did not result in a significant increase in the number of ICU-free days within 28 d in bleeding trauma, but a significant reduction in hospital LOS. Excitingly, we suggest that the effect is most pronounced in severely injured & young patients
@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus Exploratory analyses: Hospital LOS at 90 days, in patients younger than 65 years, the number of days was 11 days (prostacyclin) versus 18 days (p = 0.06), and in patients with ISS <25, it was 8 days (prostacyclin) versus 18 days (p = 0.05)
@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus Exploratory analyses we found that in patients with ISS>25, the number of ICU free days at 28 days was 10.5 days (prostacyclin) versus 0 days (p = 0.07)
@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus The significant effect on LOS is seen even stronger in diff groups of survivors
@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus The effect of low dose prostacyclin as compared to placebo
@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus The right bleeding trauma population
@JTraumAcuteSurg @Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus 242 randomized, most patients (79%) were male suffering severe trauma (median ISS, 24), blunt trauma (71%), and bleeding requiring a median of 4 U of red blood cells, 6 U of plasma, and 2 U of platelets concentrates in the first 24 hours from hospital admission
@JTraumAcuteSurg Scandinavian multicenter, randomized, placebo-controlled, blinded, investigator initiated pilot trial of low-dose continuous infusion of iloprost versus placebo
@Rigshospitalet @AUHdk @OUHhospital @Oslounivsykehus
Endotheliopathy of trauma has poor outcome. We conducted a RCT investigating 72hour prostacyclin vs placebo infusion in 229 shocked patients. No difference in the mean number of ICU-free days alive <28 days was found. A reduction in hospital stay was found https://journals.lww.com/jtrauma/fulltext/2024/03000/prostacyclin_in_trauma_patients_with_hemorrhagic.18.aspx
1/n I teach that that oedema and hypovolaemia cannot coexist at steady state, then Professor Hahn presents this intriguing experiment. Hahn’s fluid kinetic methodology has many limitations, but I’ve used his data to illustrate Revised Starling Physiology. https://www.sciencedirect.com/science/article/pii/S0959289X23003175
@nnc2023
@nnc2023 TXA is Standard Of Care in coagulopathy management of TBI
@nnc2023 In the iTACTIC trial we investigated massive trauma haemorrrhage, and when TBI added to the challenge
@nnc2023 Goaldirected care is rhe way forward in detecting and treating coagulopathy
@nnc2023 Acute Traumatic Coagulopathy can be devided in 4 main types, driven by local or systemic shock, trauma and bleeding
@nnc2023 Expanding bleeding is to be avoided, coagulopathy is central here
Coagulation in #TBI by Jakob Stensballe - two key points: coagulation is complex and adaptive #NNC2023
Teemu Luoto on epidemiology trends in #TBI in Europe #NNC2023
Prehospital TXA was associated w/ a dose-dependent decrease in circulating syndecan-1 concentrations suggesting a pro-endothelial therapeutic effect
@daniellegruen @joshua_b_brown @Guyettef @J_Stensballe @ShimenaL @ChristineLeeper @beastridge22 @TopKniFe_B
https://journals.lww.com/jtrauma/fulltext/2023/11000/prehospital_tranexamic_acid_is_associated_with_a.5.aspx
Who's confused about TXA and trauma? 🙋🏻
The data has been variable, but the best available data suggests there's a 7d mortality benefit, but 30d benefits are unclear. In this prospective study, they looked at endothelial dysfunction and found that an early, dose-dependent…
Original Article: Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia (MINT trial) https://nej.md/49rFHDG
#AHA23 @AHAScience
#MethodMonday 41: Environmental life cycle assessments
This week's paper suggested by @TineMeyhoff - thanks! Suggestions always welcome.
It covers life cycle assessments (LCAs), a method to quantify the enviromental impacts of medical practice 1/..
“High intraoperative oxygen administration has no clinically significant benefit on the incidence of postoperative nausea and vomiting.” Authors assert that intraoperative oxygen should be adjusted for oxygenation reasons only. See the editorial: https://ow.ly/9gWS50Q47X7
Vasopressin in Sepsis and Other Shock States: State of the Art
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://criticalcarereviews.com/newsletters/subscribe
Lørdagen på årsmødet, kan du møde to ledere med indsigt og visioner for medmenneskelig ledelse.
https://dasaim.dk/husk-at-koebe-billet-til-loerdagen-paa-aarsmoedet/
Anna-Marie Bloch Münster, lægelig direktør Sydvestjysk Sygehus, holder oplægget og Pernille Cedergren, cheflæge Gentofte hospital, er moderator.
A hockey player - Adam Johnson - had his carotid slashed during a hit yesterday. He ended up dying.
So, what can you do in this situation?
-Start with *accurate* direct pressure. This means very quickly wipe or clear the area so you can see where the wound is. Apply pressure…
Extracorporeal cardiopulmonary resuscitation in 2023
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://criticalcarereviews.com/newsletters/subscribe
Point-of-Care Lung Ultrasound in the Intensive Care Unit. The Dark Side of Radiology: Where Do We Stand?
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Fluid therapy in the acute brain injured patient
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://criticalcarereviews.com/newsletters/subscribe
Magnificent improvements in survival of pediatric leucaemia in Denmark #Rockstar #Research @LisaHjalgrim @KjeldSchmiegelpw @Rigshospitalet #grandrounds #StrongWork
This 👇
Early diagnosis of necrotizing fasciitis: Imaging techniquesand their combined application
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://criticalcarereviews.com/newsletters/subscribe
Tilmeldingen til DASAIMs årsmøde 2023 er nu åben🥳
TILMELDING OG PROGRAM FOR ÅRSMØDET 2023 - Dasaim
DASAIMs Årsmøde 2023 - Kontakt Sekretariatet for yderligere oplysninger.
dasaim.r2d.dk
🩸ROTEM & TEG Coagulation Testing: Excellent summary & review
👉Critical appraisal of new methodologies & current literature
🔗https://criticalcarereviews.com/latest-evidence/journal-watch
#FOAMcc #SCCMSoMe #MedEd #MedTwitter
Focused Assessment with Sonography for Trauma (FAST)
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://criticalcarereviews.com/newsletters/subscribe
Opioids are effective analgesics, but they can have harmful adverse effects. #Naloxone is currently the only available treatment for reversing the negative effects of #opioids, including respiratory depression. Learn more in the latest review article: https://ow.ly/XKvr50PxSyo
“High intraoperative oxygen administration has no clinically significant benefit on the incidence of postoperative nausea and vomiting.” Authors assert that intraoperative oxygen should be adjusted for oxygenation reasons only. See the editorial: https://ow.ly/fpe650Pt93T
Today's paper of the day is by S. Frisvold on respiratory challenges and ventilatory management in different types of acute brain-injured patients
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2023
ChatGPT-like AIs are coming to major science search engines
“General anesthesia had rendered the brains of the young patients functionally ‘rigid,’ [which] contrasts with a previous study in adults.” Dr. Sleigh discusses #anesthetic brain dynamics in #pediatric patients and its influence on day-to-day practice: https://ow.ly/32eX50Pqhqz
Big Decisions for Our Little Patients: Mask vs. IV Inductions
@_Anesthesiology #MedEd #MedTwitter #Anesthesiology
https://pubs.asahq.org/anesthesiology/article/128/6/A19/19872/Big-Decisions-for-Our-Little-Patients-Mask-vs-IV
Today's paper of the day is by Brent A. Bagley on care of the critically injured burn patient
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2023
Today's paper of the day is by Ann-Sophie Kaemmerer on pericardial tamponade, a diagnostic chameleon: from the historical perspectives to contemporary management
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Contemporary Vasopressor and Inotrope Use in Cardiogenic Shock
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://criticalcarereviews.com/newsletters/subscribe
Treatment of pediatric convulsive status epilepticus
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://criticalcarereviews.com/newsletters/subscribe
Intravenous application of #epinephrine induced marked cerebral microvascular constriction, intravascular hemoglobin desaturation, and paradoxically, an increase in brain tissue oxygen levels, likely due to reduced transit time heterogeneity. Learn more: https://ow.ly/TWuX50Pa079
Among older adults, spinal and general #anesthesia produce similar outcomes across a range of studies. Authors highlighted key evidence and opportunities for further research: https://ow.ly/2bLk50P9ZLy
Perioperative Quality Improvement is central to the role of the #anaesthesia team. New textbook edited by Prof Carol Peden & Prof Lee Fleisher, reviewed by Benjamin Andrew.
https://www.bjanaesthesia.org/article/S0007-0912(23)00233-7/fulltext
Smerteudvalget ønsker at henlede opmærksomheden
SSAI Obstetric Anesthesia Efteruddannelse for
4-6 eksklusive sponsorer: I forbindelse
De aktive medlemmer i selskabet udfører et stort, ulønnet arbejde til gavn for alle dele af specialet og dit medlemskab er med til at støtte initiativerne.